The premise of the game is that God has a program on his computer where you get to "fuck with humans" by smashing them with your big fist. I guess this is the Old Testament God and not the New Testament God--though I've never seen much difference between the two; they both like to mess with mankind (and women too).
I've done several cartoons along the same lines as the theme of this game. Either God enjoys messin' with us and cannot have empathy for the pain it causes or God is simply apathetic and doesn't care.
The most rational solution though is that there really isn't a God and that we humans made him up to explain the unexplainable.